James Brown Selected Research

AMG 333

1/2018

Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

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James Brown Research Topics

Disease

15	Neoplasms (Cancer) 06/2022 - 06/2006
5	Alzheimer Disease (Alzheimer's Disease) 02/2015 - 01/2004
3	Hemorrhage 01/2021 - 01/2006
3	Colonic Neoplasms (Colon Cancer) 10/2019 - 08/2006
3	Infections 10/2018 - 03/2015
3	Tuberculosis (Tuberculoses) 01/2018 - 10/2016
3	Breast Neoplasms (Breast Cancer) 02/2012 - 04/2010
2	Vomiting 04/2022 - 01/2011
2	Nausea 04/2022 - 01/2011
2	Cardiomyopathies (Cardiomyopathy) 01/2022 - 01/2022
2	Pneumonia (Pneumonitis) 07/2020 - 03/2014
2	Lung Diseases (Lung Disease) 07/2020 - 10/2019
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2019 - 09/2015
2	Myocardial Infarction 01/2019 - 01/2006
2	Surgical Wound Infection 10/2018 - 01/2018
2	Alcoholism (Alcohol Abuse) 01/2017 - 04/2010
2	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 03/2016 - 01/2015
2	Renal Cell Carcinoma (Grawitz Tumor) 07/2015 - 12/2009
2	Pain (Aches) 11/2011 - 01/2011
2	Opioid-Related Disorders (Opiate Addiction) 11/2011 - 01/2011
2	Thrombosis (Thrombus) 06/2005 - 02/2005
1	Congenital Heart Defects (Congenital Heart Defect) 10/2022
1	Graft vs Host Disease (Graft-Versus-Host Disease) 06/2022
1	Lymphopenia (Lymphocytopenia) 05/2022
1	Hematologic Neoplasms (Hematological Malignancy) 05/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 01/2022
1	Amyloidosis 01/2022
1	Venous Thromboembolism 10/2021
1	Hypertrophy 05/2021
1	Infarction (Infarctions) 01/2021
1	Ischemia 01/2021
1	COVID-19 01/2021
1	Coronary Disease (Coronary Heart Disease) 01/2021
1	Shock 06/2020
1	Aortic Dissection 06/2020
1	Parkinson Disease (Parkinson's Disease) 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Sepsis (Septicemia) 10/2019
1	Critical Illness (Critically Ill) 10/2019
1	Sarcoidosis (Schaumann Disease) 10/2019
1	Macular Degeneration (Age-Related Maculopathy) 03/2019
1	Glaucoma 03/2019
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2019
1	Hypersensitivity (Allergy) 10/2018
1	Contact Dermatitis (Eczema, Contact) 10/2018
1	Platypnea Orthodeoxia Syndrome 05/2018

Drug/Important Bio-Agent (IBA)

7	Pharmaceutical PreparationsIBA 01/2017 - 04/2010
5	Amyloid (Amyloid Fibrils)IBA 01/2022 - 02/2015
3	Chimeric Antigen ReceptorsIBA 06/2022 - 05/2022
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 12/2009
3	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 02/2011
2	Prealbumin (Transthyretin)IBA 01/2022 - 01/2022
2	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 01/2020
2	Therapeutic UsesIBA 03/2019 - 04/2010
2	AcidsIBA 01/2018 - 02/2017
2	CopperIBA 01/2017 - 04/2010
2	Disulfiram (Antabuse)FDA Link 01/2017 - 04/2010
2	AntigensIBA 11/2016 - 11/2010
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2015 - 11/2012
2	Ethanol (Ethyl Alcohol)IBA 01/2014 - 02/2009
2	AntioxidantsIBA 01/2013 - 02/2009
2	Biomarkers (Surrogate Marker)IBA 02/2012 - 02/2011
2	Phenobarbital (Luminal)FDA Link 01/2012 - 10/2007
2	Opioid Analgesics (Opioids)IBA 11/2011 - 01/2011
2	Insulin-Like Growth Factor II (Somatomedin A)IBA 01/2008 - 06/2006
2	CalciumIBA 04/2007 - 04/2006
2	CholesterolIBA 08/2004 - 01/2004
1	Interleukin-2 (IL2)IBA 06/2022
1	Interleukin-15 (Interleukin 15)IBA 06/2022
1	AntiemeticsIBA 04/2022
1	Ondansetron (Zofran)FDA LinkGeneric 04/2022
1	Neoplasm Antigens (Tumor Antigens)IBA 01/2022
1	GadoliniumIBA 01/2021
1	TroponinIBA 01/2021
1	CreatinineIBA 06/2020
1	Immune Checkpoint InhibitorsIBA 01/2020
1	LigandsIBA 01/2020
1	durvalumabIBA 01/2020
1	RNA (Ribonucleic Acid)IBA 10/2019
1	Immunologic Adjuvants (Immunologic Adjuvant)IBA 10/2019
1	Bronchodilator Agents (Bronchodilators)IBA 01/2019
1	Contraceptive Agents (Contraceptives)IBA 10/2018
1	NickelIBA 10/2018
1	Saline SolutionIBA 05/2018

Therapy/Procedure

9	Therapeutics 06/2022 - 01/2004
6	Immunotherapy 06/2022 - 05/2019
2	Lung Transplantation 10/2021 - 10/2019
2	Blood Transfusion (Blood Transfusions) 07/2020 - 06/2020
2	Cesarean Section (Caesarean Section) 10/2018 - 01/2018
2	Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump) 06/2005 - 02/2005
1	Enteral Nutrition (Feeding, Tube) 10/2022
1	Salpingectomy 01/2022
1	Contraception (Birth Control) 01/2022
1	Diathermy 01/2021
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 07/2020
1	Art Therapy 07/2020
1	Hemodilution 07/2020
1	Transplantation 10/2019
1	Length of Stay 01/2019